Joint time and frequency transfer through one International Telecommunication Union 100 GHz wavelength division multiplexing channel with commercial devices.

We proposed a joint time and frequency transfer scheme over a single International Telecommunication Union 100 GHz wavelength division multiplexing (WDM) channel using a normal commercial WDM device and commercial offset WDM device. A standard 100 GHz WDM channel is divided into three sub-channels with a frequency interval of more than 20 GHz for a time and frequency transfer, which could help to avoid the interference among time, frequency, and data signals in other WDM channels. A joint high-precision time and frequency transfer is, therefore, able to be performed with data transmission over WDM optical communication links without extra requirements on devices. A joint time and frequency transfer in a single 100 GHz WDM channel is experimentally demonstrated over a 60 km fiber link with the communication data transmission in the adjacent channels. The stability of the time transfer can be better than 15 ps at 1 s, and the stability of the frequency transfer can be better than 2.7×10-14 at 1 s, while the bit error rates of the adjacent channels are at the same level as the separate transmission.

Abortion storm of Yili horses is associated with Equus caballus papillomavirus 2 variant infection.

Nine different species of Equus caballus papillomavirus (EcPV) and three bovine papillomaviruses (BPVs) have been reported to infect horses. However, there are few descriptions of such infections in China. In our pioneer study on Chinese horses, we identified EcPV-2 in the nasal swabs (4/230, 1.7%) of Yili horses, and the semen (3/18, 16.7%) of thoroughbred horses. This indicated that EcPV is indeed hosted by horses in China, and that EcPV-2 might be transmitted though breeding. Further detection of EcPVs in the lung tissues of aborted fetuses of Yili horses, which were originally negative for equid herpes viruses, demonstrated EcPV-2 positivity in 19 of 50 samples, thereby indicating that EcPV-2 may be a new pathogen responsible for causing abortion. Thereafter, sequence analyses of the L1 genes of 26 EcPV-2 in China were performed, indicating that EcPV-2, which primarily infects horses in China, shared 98.3-99.9% nt identity with the published sequences for EcPV-2. These observations indicated that EcPV-2 identified in the current study were highly similar variants of the previously identified strains of EcPV-2. Phylogenetic analysis based on L1 gene sequences from GenBank showed that the EcPV-2 found in Chinese horses was closely related to and clustered together with an already known EcPV-2a lineage. Our study provides the first evidence related to EcPV-2 infection in Chinese horses, which can serve as a causative agent for Yili horse abortions, and may thus lay the foundation for a systematic and detailed epidemiological study of this infection in Chinese horses.

Photonic millimeter-wave transfer with balanced dual-heterodyne phase noise detection and cancellation.

We report on the realization of long-haul and high-precision millimeter-wave (mm-wave) transfer through a fiber-optic link based on balanced dual-heterodyne phase noise detection. The balanced dual-heterodyne detection is achieved by detecting the fiber phase noise superimposed two intermediate frequency (IF) signals without requiring a local synchronization signal and its output is used to compensate the fiber-induced phase noise by actuating the frequency of the one optical carrier. The proposed scheme can effectively get rid of the effect of the local reference, largely simplifying the configuration at the local site. Additionally, we model and experimentally study the noise contribution coming from the out-of-band, which can be effectively suppressed to the below of the system noise floor with a fractional frequency instability of 1.9 × 10-17 at 10,000 s by designing and implementing a high-precision temperature control module with a peak-to-peak temperature fluctuation of no more than 0.002 K. We experimentally demonstrate that a 100 GHz mm-wave signal to be transmitted over a 150 km fiber-optic link can achieve the fractional frequency instabilities of less than 3.4 × 10-14 at 1 s and 3.5 × 10-17 at 10,000 s.

A meta-analysis of randomized controlled trials of tonifying kidney and strengthen bone therapy on nondialysis patients with chronic kidney disease-mineral and bone disorder.

BACKGROUND: Correction of calcium, phosphorus, and parathyroid hormone disorders is the standard of treatment in nondialysis patients with chronic kidney disease-mineral and bone disorder (CKD-MBD). However, the side effects and adverse reactions are still the main problems. Moreover, the lack of protection of kidney function in the treatment dramatically affects patients' health. Although Traditional Chinese Medicine, specifically tonifying kidney and strengthen bone (TKSB) therapy, is wildly applied to patients with CKD-MBD in China, the evidence of TKSB therapy in the treatment of CKD-MBD is limited. Thus, we conducted this meta-analysis to evaluate the efficacy and safety of TKSB therapy combined with Western medicine (WM) for nondialysis patients with CKD-MBD. METHODS: Two investigators conducted systematic research of randomized controlled trials of TKSB therapy for CKD-MBD from 7 electronic databases. Methodological quality evaluations were performed using the Cochrane collaboration tool, and data analysis was conducted by RevMan v5.3 software and STATA v15.0. RESULTS: In total, 8 randomized controlled trials involving 310 patients met the criteria of meta-analysis. The complete results showed that compared with WM alone, TKSB treatment could improve the clinical efficacy rate (risk ratio = 4.49, 95% confidence interval [CI]: [2.64, 7.61], P  .00001), calcium (weighted mean difference [WMD] = 0.11, 95% CI: [0.08, 0.14], P < .00001), serum creatinine (WMD = 45.58, 95% CI: [32.35, 58.8], P < .00001) phosphorus (WMD = 0.11, 95% CI: [0.08, 0.13], P < .00001), parathyroid hormone (WMD = 16.72, 95% CI: [12.89, 20.55], P < .00001), blood urea nitrogen levels (WMD = 0.95, 95% CI: [0.26, 1.64], P = .007) on nondialysis patients with CKD-MBD, which was beneficial to improve the patients' bone metabolic state and renal function. In addition, evidence shows that, compared with WM alone, TKSB treatment is safe and does not increase side effects. CONCLUSION: The systematic review found that TKSB therapy combined with WM has a positive effect on improving renal function and correcting bone metabolism disorder in nondialysis patients with CKD-MBD, which shows that Traditional Chinese Medicine is effective and safe in treating CKD-MBD. However, more high-quality, large-sample, multicenter clinical trials should be conducted to assess the safety and efficacy of TKSB therapy in treating nondialysis patients with CKD-MBD.Systematic review registration: INPLASY2020120086.

Log odds of positive lymph nodes as a novel prognostic predictor for gastric cancer: a systematic review and meta-analysis.

BACKGROUND: We conducted a systematic review and meta-analysis to summarize the predictive and prognostic ability of the log odds of positive lymph nodes (LODDS) staging system and compare it with pathological N (pN) classification and the ratio-based lymph node system (rN) for the overall survival (OS) of gastric cancer (GC). METHODS: Through a systematic review till March 7, 2022, we identified population-based studies that reported the prognostic effects of LODDS in patients with GC. We compare the predictive effectiveness of the LODDS staging system with that of the rN and pN classification systems for the OS of GC. RESULTS: Twelve studies comprising 20,312 patients were included in this systematic review and meta-analysis. The results showed that LODDS1, LODDS2, LODDS3, and LODDS4 in GC patients were correlated with poor OS compared with LODDS0 (LODDS1 vs. LODDS0: HR = 1.62, 95% CI (1.42, 1.85); LODDS2 vs. LODDS0: HR = 2.47, 95% CI (2.02, 3.03); LODDS3 vs. LODDS0: HR = 3.15, 95% CI (2.50, 3.97); LODDS4 vs. LODDS0: HR = 4.55, 95% CI (3.29, 6.29)). Additionally, significant differences in survival were observed among patients with different LODDS classifications (all P-values were < 0.001) with the same rN and pN classifications. Meanwhile, for patients with different pN or rN classifications with the same LODDS classification, prognosis was highly similar. CONCLUSION: The findings show that LODDS is correlated with the prognosis of GC patients and is superior to the pN and rN classifications for prognostic assessment.

[Ketogenic diet improves low temperature tolerance in mice by up-regulating PPARα in the liver and brown adipose tissue].

The aim of the present study was to investigate the effects of short-term ketogenic diet on the low temperature tolerance of mice and the involvement of peroxisome proliferator-activated receptor α (PPARα). C57BL/6J mice were divided into two groups: normal diet (WT+ND) group and ketogenic diet (WT+KD) group. After being fed with normal or ketogenic diet at room temperature for 2 d, the mice were exposed to 4 °C low temperature for 12 h. The changes in core temperature, blood glucose, blood pressure of mice under low temperature condition were detected, and the protein expression levels of PPARα and mitochondrial uncoupling protein 1 (UCP1) were detected by Western blot. PPARα knockout mice were divided into normal diet (PPARα-/-+ND) group and ketogenic diet (PPARα-/-+KD) group. After being fed with the normal or ketogenic diet at room temperature for 2 d, the mice were exposed to 4 °C low temperature for 12 h. The above indicators were also detected. The results showed that, at room temperature, the protein expression levels of PPARα and UCP1 in liver and brown adipose tissue of WT+KD group were significantly up-regulated, compared with those of WT+ND group. Under low temperature condition, compared with WT+ND, the core temperature and blood glucose of WT+KD group were increased, while mean arterial pressure was decreased; The ketogenic diet up-regulated PPARα protein expression in brown adipose tissue, as well as UCP1 protein expression in liver and brown adipose tissue of WT+KD group. Under low temperature condition, compared to WT+ND group, PPARα-/-+ND group exhibited decreased core temperature and down-regulated PPARα and UCP1 protein expression levels in liver, skeletal muscle, white and brown adipose tissue. Compared to the PPARα-/-+ND group, the PPARα-/-+KD group exhibited decreased core temperature and did not show any difference in the protein expression of UCP1 in liver, skeletal muscle, white and brown adipose tissue. These results suggest that the ketogenic diet promotes UCP1 expression by up-regulating PPARα, thus improving low temperature tolerance of mice. Therefore, short-term ketogenic diet can be used as a potential intervention to improve the low temperature tolerance.

Pulsed microwave photonic vector network analyzer based on direct sampling.

Pulsed VNAs enabling large dynamic measurement at a low pulse duty cycle are necessary for the characterization of active devices due to the overheating damage risk under continuous wave stimulation. In this paper, we proposed a pulsed microwave photonic vector network analyzer (p-MPVNA) based on direct sampling. With the broad system bandwidth of the p-MPVNA and undersampling technique, pulsed signals are received thru asynchronous wideband detection, and pulsed S-parameters are calculated thru vector superposition. In asynchronous wideband detection, the continuous spectrum of the pulsed signal is discretized into multiple frequency components. A low repetition rate optical pulse train undersamples the pulsed signal, and the discretized frequency components are aliased. The frequency components in the main lobe including most energy of the pulse signal are vector superimposed to calculate the pulsed S-parameter. The proposed p-MPVNA has a dynamic range decreases rate of 10log(duty cycle) when pulse duty cycle is below 10% , which is much slower than that of 20log(duty cycle) for classical narrowband detection. An experimental p-MPVNA is established for validation. A 6 to 18 GHz microwave amplifier is measured with continuous and pulsed power supply and the measured gain curves are consistent with the results from a commercial VNA. The system dynamic range decrease with pulse duty cycle is verified by the pulsed S-parameter measurement of a 10 GHz low pass filter under continuous and pulsed stimulation.

Temperature-dependent metabolite orchestration to acute submaximal exercise indicates cardiorespiratory fitness in humans.

AIMS: Cardiorespiratory fitness (CRF), an important biomarker of human health, is impaired in cold environment compared to thermoneutral condition. The study aimed to investigate the role of metabolome response to acute exercise in regulation of CRF at different ambient temperatures. MAIN METHODS: A total of 27 young adults were recruited, and each subject underwent a cardiopulmonary exercise test (CPET) and a constant load submaximal exercise at both room temperature (25 °C) and cold temperature (0 °C). The serum samples were collected before and immediately after constant load exercise. KEY FINDINGS: Acute cold exposure decreased CRF by 41 %, accompanied by a metabolic shift to anaerobic respiration. It also decreased VO2 and increased respiratory quotient during constant load exercise. Metabolome profiling revealed that acute exercise reprogrammed serum metabolome in an ambient temperature-dependent manner. Specifically, exercise increased a cluster of fatty acids during cold exposure, possibly due to impaired fatty acid oxidation. The correlations between metabolite responses to acute exercise and exercise parameters were analyzed using partial least squares regression and machine learning, revealing that metabolite responses to acute exercise were highly correlated with exercise parameters and predictive of CRF. Among the contributors, tryptophan and its metabolites stood out as important ones. SIGNIFICANCE: These results suggested that the metabolite responses to acute submaximal exercise unmasks the exercise performance at different ambient temperatures, highlighting the role of metabolite orchestration in the physiological regulation of CRF.

Effects of marital status on survival of retroperitoneal liposarcomas stratified by age and sex: A population-based study.

BACKGROUND: Previous studies have shown that marital status is associated with survival in patients with a variety of cancer types, including lung cancer, prostate cancer, and bladder cancer. However, to date, the impact of marital status on the survival of patients with retroperitoneal liposarcomas (RPLs) has not been established. METHODS: A total of 1211 eligible patients diagnosed with RPLs were identified in the Surveillance, Epidemiology, and End Results (SEER) database. The relationships between marital status and survival in patients with RPLs were assessed. Patients were stratified by age to determine whether an association exists between marital status and age. We also probed the association between marital status and survival in males and females. RESULTS: Our findings suggest that divorced, separated, or widowed patients have more advanced cancer stages, and more of these patients do not undergo surgery. Meanwhile, divorced, separated, or widowed patients have worse survival outcomes than married patients (overall survival (OS): HR = 1.66 (95% CI, 1.12, 2.46)); cancer-specific survival (CSS): HR = 1.90 (95% CI, 1.13, 3.19)). OS does not differ between single patients and married patients (HR = 1.21 [95% CI, 0.81, 1.81]) or CSS (HR = 1.36 [95% CI, 0.80, 2.29]). In addition, these results demonstrate that being divorced, separated, or widowed can play a significant detrimental role in mortality in older and female patients. CONCLUSION: Married patients have earlier disease stages at diagnosis and better survival outcomes than divorced, separated, or widowed patients with RPLs. In addition, this effect is especially pronounced in older people and females.

Fast and on-line link optimization for the long-distance two-way fiber-optic time and frequency transfer.

The performance of long-distance two-way fiber-optic time and frequency (T/F) transfer is directly affected by link parameters. In this paper, a fast on-line scheme to maximize the signal-to-noise ratio at the T/F transfer link ends (denoted by SNRW and SNRE) is proposed by optimizing the gains of bidirectional Erbium-doped fiber amplifiers (Bi-EDFAs). The dedicatedly defined objective optimization functions, ln(1/SNRW + 1/SNRE) for microwave and time transfer, and ln(1/SNRW) for optical frequency transfer, are proven to be a convex function and enable the computation time to be reduced significantly by employing the fast and mature convex optimization algorithm. The linear equations about the objective optimization function and the fiber parameters required by optimization are constructed, and then the fiber parameters are proposed to be on-line obtained accordingly by measuring the concerned SNR at the link end under different EDFA gain configurations and solving the linear equations. The transmission matrixes for the proposed optimization scheme are further derived, which can simplify the implementation in the long-distance multiple EDFAs links. The simulation shows that the proposed algorithm can obtain the optimal parameters consistent with the reported experimental results, and can reduce the computation time by more than four orders compared with the scanning optimization method for a link with more than 6 Bi-EDFAs.

Multiple-access relay stations for long-haul fiber-optic radio frequency transfer.

We report on the realization of a long-haul radio frequency (RF) transfer scheme by using multiple-access relay stations (MARSs). The proposed scheme with independent link noise compensation for each fiber sub-link effectively solves the limitation of compensation bandwidth for long-haul transfer. The MARS can have the capability to share the same modulated optical signal for the front and rear fiber sub-links, simplifying the configuration at the repeater station and enabling the transfer system to have the multiple-access capability. At the same time, we for the first time theoretically model the effect of the MARS position on the fractional frequency instability of the fiber-optic RF transfer, demonstrating that the MARS position has little effect on system's performance when the ratio of the front and rear fiber sub-links is around 1:1. We experimentally demonstrate a 1 GHz signal transfer by using one MARS connecting 260 and 280 km fiber links with the fractional frequency instabilities of less than 5.9 × 10-14 at 1 s and 8.5 × 10-17 at 10,000 s at the remote site and of 5.6 × 10-14 and 6.6 × 10-17 at the integration times of 1 s and 10,000 s at the MARS. The proposed scalable technique can arbitrarily add the same MARSs in the fiber link, which has great potential in realizing ultra-long-haul RF transfer.

Development and Validation of a Prognostic Model to Predict the Prognosis of Patients With Retroperitoneal Liposarcoma: A Large International Population-Based Cohort Study.

Background: Retroperitoneal liposarcomas (RPLs), sarcoma of mesenchymal origin, are the most common soft tissue sarcomas (STS) of the retroperitoneum. Given the rarity of RPLs, the prognostic values of clinicopathological features in the patients remain unclear. The nomogram can provide a visual interface to aid in calculating the predicted probability that a patient will achieve a particular clinical endpoint and communication with patients. Methods: We included a total of 1,392 RPLs patients diagnosed between 2004 and 2015 from the Surveillance, Epidemiology, and End Results (SEER) database. For nomogram construction and validation, patients in the SEER database were divided randomly into the training cohort and internal validation cohort at a ratio of 7:3, while 65 patients with RPLs from our center between 2010 and 2016 served as the external validation cohort. The OS curves were drawn using the Kaplan-Meier method and assessed using the log-rank test. Moreover, Fine and Gray's competing-risk regression models were conducted to assess CSS. Univariate and multivariate analyses were performed to select the prognostic factors for survival time. We constructed a predictive nomogram based on the results of the multivariate analyses. Results: Through univariate and multivariate analyses, it is found that age, histological grade, classification, SEER stage, surgery constitute significant risk factors for OS, and age, classification, SEER stage, AJCC M stage, surgery, and tumor size constitute risk factors for CSS. We found that the nomogram provided a good assessment of OS and CSS at 1, 3, and 5 years in patients with RPLs (1-year OS: (training cohort: AUC = 0.755 (95% CI, 0.714, 0.796); internal validation cohort: AUC = 0.754 (95% CI, 0.681, 0.827); external validation cohort: AUC = 0.793 (95% CI, 0.651, 0.935)); 3-year OS: (training cohort: AUC = 0.782 (95% CI, 0.752, 0.811); internal validation cohort: AUC = 0.788 (95% CI, 0.736, 0.841); external validation cohort: AUC = 0.863 (95% CI, 0.773, 0.954)); 5-year OS: (training cohort: AUC = 0.780 (95% CI, 0.752, 0.808); internal validation cohort: AUC = 0.783 (95% CI, 0.732, 0.834); external validation cohort: AUC = 0.854 (95% CI, 0.762, 0.945)); 1-year CSS: (training cohort: AUC = 0.769 (95% CI, 0.717, 0.821); internal validation cohort: AUC = 0.753 (95% CI, 0.668, 0.838); external validation cohort: AUC = 0.799 (95% CI, 0.616, 0.981)); 3-year CSS: (training cohort: AUC = 0.777 (95% CI, 0.742, 0.811); internal validation cohort: AUC = 0.787 (95% CI, 0.726, 0.849); external validation cohort: AUC = 0.808 (95% CI, 0.673, 0.943)); 5-year CSS: (training cohort: AUC = 0.773 (95% CI, 0.741, 0.805); internal validation cohort: AUC = 0.768 (95% CI, 0.709, 0.827); external validation cohort: AUC = 0.829 (95% CI, 0.712, 0.945))). The calibration plots for the training, internal validation, and external validation cohorts at 1-, 3-, and 5-year OS and CSS indicated that the predicted survival rates closely correspond to the actual survival rates. Conclusion: We constructed and externally validated an unprecedented nomogram prognostic model for patients with RPLs. The nomogram can be used as a potential, objective, and supplementary tool for clinicians to predict the prognosis of RPLs patients around the world.

Exercise Enhances Branched-Chain Amino Acid Catabolism and Decreases Cardiac Vulnerability to Myocardial Ischemic Injury.

Long-term exercise-induced metabolic adaptations occupy a central position in exercise-afforded cardiac benefits. Emerging evidence suggests that branched-chain amino acid (BCAA) catabolic defect contributes to cardiac dysfunction in multiple cardiometabolic diseases. However, the role of BCAA catabolism in exercise-afforded cardiac benefits remains unknown. Here, we show that exercise improves BCAA catabolism and thus reduce cardiac vulnerability to myocardial ischemic injury. Exercise increased circulating BCAA levels in both humans (male adolescent athletes) and mice (following an 8-week swimming intervention). It increased the expression of mitochondrial localized 2C-type serine-threonine protein phosphatase (PP2Cm), a key enzyme in regulating BCAA catabolism, and decreased BCAA accumulation in mouse hearts, indicating an increase in BCAA catabolism. Pharmacological promotion of BCAA catabolism protected the mouse heart against myocardial infarction (MI) induced by permanent ligation of the left descending coronary artery. Although cardiac-specific PP2Cm knockout showed no significant effects on cardiac structural and functional adaptations to exercise, it blunted the cardioprotective effects of exercise against MI. Mechanistically, exercise alleviated BCAA accumulation and subsequently inactivated the mammalian target of rapamycin in MI hearts. These results showed that exercise elevated BCAA catabolism and protected the heart against myocardial ischemic injury, reinforcing the role of exercise in the promotion of cardiac health.

Molecular characteristics and pathogenicity of an equid alphaherpesvirus 1 strain isolated in China.

Equid alphaherpesvirus 1 (EHV-1) is prevalent in China, and causes notable economic damage to the equine industry. However, there is no information regarding the molecular characteristics and pathogenicity of the Chinese strains. Therefore, an EHV-1 strain, named YM2019, was isolated from the lung tissue of an aborted horse fetus in Xinjiang, China, and its genome and pathogenicity were analyzed. The full genome of the isolate was 150,267 base pairs in length, with 56.7% G + C content. Genetic and phylogenetic analysis showed that strain YM2019 (GenBank: MT063054) belonged to the ORF30 N752 genotype but displayed a high level of similarity with strain Ab4 (ORF30 D752, GenBank: AY665713) isolated in Britain. Fourteen unique amino acid mutations were found when comparing strain YM2019 with the reference strains Ab4 and V592 (ORF30 N752, GenBank: AY464052). Syrian hamsters infected with strain YM2019 exhibited severe respiratory and neurological clinical signs and died. Infection with strain YM2019 in Yili horses caused rhinopneumonitis, viremia, and neurological clinical signs such as hind limb lameness, prostration, and reduced movement. Here, we describe the features of an EHV-1 strain discovered in China, together with the complete genome sequence, and reveal that a nonneurovirulent strain (ORF30 N752) can also cause neurological signs in horses. The data will be useful in providing some reference for further research into the relationship between viral genotypes and pathogenicity.

Log odds of positive lymph nodes as a novel prognostic predictor for colorectal cancer: a systematic review and meta-analysis.

BACKGROUND: Colorectal cancer (CRC) is the third most prevalent cancer in the world, which remains one of the leading causes of cancer-related deaths. Accurate prognosis prediction of CRC is pivotal to reduce the mortality and disease burden. Lymph node (LN) metastasis is one of the most commonly used criteria to predict prognosis in CRC patients. However, inaccurate surgical dissection and pathological evaluation may lead to inaccurate nodal staging, affecting the effectiveness of pathological N (pN) classification in survival prediction among patients with CRC. In this meta-analysis, we aimed to estimate the prognostic value of the log odds of positive lymph nodes (LODDS) in patients with CRC. METHODS: PubMed, Medline, Embase, Web of Science and the Cochrane Library were systematically searched for relevant studies from inception to July 3, 2021. Statistical analyses were performed on Stata statistical software Version 16.0 software. To statistically assess the prognostic effects of LODDS, we extracted the hazard ratio (HR) and 95% confidence interval (CI) of overall survival (OS) and disease-free survival (DFS) from the included studies. RESULTS: Ten eligible articles published in English involving 3523 cases were analyzed in this study. The results showed that LODDS1 and LODDS2 in CRC patients was correlated with poor OS compared with LODDS0 (LODDS1 vs. LODDS0: HR = 1.77, 95% CI (1.38, 2.28); LODDS2 vs. LODDS0: HR = 3.49, 95% CI (2.88, 4.23)). Meanwhile, LODDS1 and LODDS2 in CRC patients was correlated with poor DFS compared with LODDS0 (LODDS1 vs. LODDS0: HR = 1.82, 95% CI (1.23, 2.68); LODDS2 vs. LODDS0: HR =3.30, 95% CI (1.74, 6.27)). CONCLUSIONS: The results demonstrated that the LODDS stage was associated with prognosis of CRC patients and could accurately predict the prognosis of patients with CRC.

The obesity paradox in patients with colorectal cancer: a systematic review and meta-analysis.

CONTEXT: Obesity is widely regarded as an established risk factor for colorectal cancer (CRC). However, recent studies have shown that lower mortality and better cancer-specific survival were observed in CRC patients with elevated body mass index (BMI), an example of the obesity paradox, which is the inverse correlation between obesity and mortality in some populations. OBJECTIVE: The aim of this systematic review and meta-analysis was to investigate the association between BMI and CRC outcomes. DATA SOURCES: PubMed, Web of Science, MEDLINE, the Cochrane Library, and Embase databases were searched for relevant articles published from inception to December 31, 2020. STUDY SELECTION: Studies comparing the prognosis of CRC patients with obesity or overweight with that of normal-weight CRC patients were eligible. DATA EXTRACTION: Data were extracted by 2 reviewers independently; differences were resolved by a third reviewer. BMI was classified according to WHO categories. DATA ANALYSIS: To assess the prognostic effects of different BMI categories in CRC patients, hazard ratios and 95%CIs of overall survival, disease-free survival, and cancer-specific survival were extracted from included articles. RESULTS: Sixteen studies (55 391 patients in total) were included. Higher BMI was significantly associated with more favorable CRC outcomes. Compared with normal-weight patients, underweight patients had worse overall survival (HR = 1.26; 95%CI, 1.15-1.37) and disease-free survival (HR = 1.19; 95%CI, 1.11-1.27, while patients with overweight had better overall survival (HR = 0.92; 95%CI, 0.86-0.99), disease-free survival (HR = 0.96; 95%CI, 0.93-1.00), and cancer-specific survival (HR = 0.86; 95%CI, 0.76-0.98). Patients with morbid obesity had worse overall survival (HR = 1.12; 95%CI, 1.02-1.22) and disease-free survival (HR = 1.15; 95%CI, 1.07-1.24) than normal-weight patients. There was no significant difference in cancer-specific survival between patients with obesity (HR = 0.94; 95%CI, 0.76-1.16) and patients with normal weight, nor between patients with underweight and patients with normal weight (HR = 1.14; 95%CI, 0.82-1.58). CONCLUSIONS: CRC patients with a higher BMI appear to have reduced mortality compared with normal-weight CRC patients, even though higher BMI/obesity is an established determinant for the development of CRC. SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. CRD42020202320.

Fiber-optic joint time and frequency transmission with enhanced time precision.

We propose a high-precision joint time and frequency transmission scheme based on bidirectional wavelength division multiplexing transmission over an optical fiber link. The time signal is generated based on the phase-stable frequency signal with employment of a dedicated designed low-jitter event generator. Time synchronization is realized by eliminating the time difference between the time signals of the master and slave stations, which is determined by accurate two-way time comparison. In this way, thanks to the high stability of the frequency transmission, low jitter of the dedicated designed event generator, and the high accuracy of the two-way time comparison, a high precision time signal with enhanced time stability and accuracy can be obtained at the slave station, which is synchronized to the master station. Experimentally, a joint time and frequency transmission system is demonstrated over a 62-km urban fiber link. The results show a time stability in terms of time deviation (TDEV) of 3.5 ps/s and 430 fs/10,000 s, and an accuracy of better than 20 ps can be realized.

Exercise promotes angiogenesis by enhancing endothelial cell fatty acid utilization via liver-derived extracellular vesicle miR-122-5p.

BACKGROUND: Angiogenesis constitutes a major mechanism responsible for exercise-induced beneficial effects. Our previous study identified a cluster of differentially expressed extracellular vesicle microRNAs (miRNAs) after exercise and found that some of them act as exerkines. However, whether these extracellular vesicle miRNAs mediate the exercise-induced angiogenesis remains unknown. METHODS: A 9-day treadmill training was used as an exercise model in C57BL/6 mice. Liver-specific adeno-associated virus 8 was used to knock down microRNA-122-5p (miR-122-5p). Human umbilical vein endothelial cells were used in vitro. RESULTS: Among these differentially expressed extracellular vesicle miRNAs, miR-122-5p was identified as a potent pro-angiogenic factor that activated vascular endothelial growth factor signaling and promoted angiogenesis both in vivo and in vitro. Exercise increased circulating levels of miR-122-5p, which was produced mainly by the liver and shuttled by extracellular vesicles in mice. Inhibition of circulating miR-122-5p or liver-specific knockdown of miR-122-5p significantly abolished the exercise-induced pro-angiogenic effect in skeletal muscles, and exercise-improved muscle performance in mice. Mechanistically, miR-122-5p promoted angiogenesis through shifting substrate preference to fatty acids in endothelial cells, and miR-122-5p upregulated endothelial cell fatty-acid utilization by targeting 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT1). In addition, miR-122-5p increased capillary density in perilesional skin tissues and accelerated wound healing in mice. CONCLUSION: These findings demonstrated that exercise promotes angiogenesis through upregulation of liver-derived extracellular vesicle miR-122-5p, which enhances fatty acid utilization by targeting AGPAT1 in endothelial cells, highlighting the therapeutic potential of miR-122-5p in tissue repair.

Interference and frequency-to-time mapping based high anti-jamming and anti-interception frequency hopping receiving.

We have proposed an interference and frequency-to-time mapping based high anti-jamming and anti-interception frequency hopping receiving scheme. By changing the delay difference between the interference arms through high-speed switchable delay lines and using electrooptical sampling, fast and large-range frequency hopping signals can be received. Benefited from the high shaping resolution for using the interference as the spectral shaping method, more receiving passbands in high frequency bands can be available to enhance the anti-jamming and anti-interception performance. By fast pulse shaping through switchable delay lines, the bandwidth of the electric end, the sampling rate, and the number of frequencies in the frequency hopping pattern are decoupled, and the bandwidth of the electric end can be reduced to improve the receiving selectivity. In experiments, the signal hopping from 15.2 GHz to 35.4 GHz with the switching time up to that of the used optical switch is received. Utilizing a switchable delay line in the interference arm with the tuning step of 2.5 ps, eight available receiving passbands within 25 GHz to 42 GHz are generated. The receiving selectivity is also improved from 18.3 to 43.7 in terms of Q factor by decreasing the electric end's bandwidth in experiments.